Type 2 Diabetes: a multi-OMIc view on host NAPH oxidases (NOx) and gut microbiota
Abstract: Development of type 2 diabetes(T2D) is a very complex, gradual and heterogeneous process. Importantly, diabetic individuals exhibit differences in terms of gut microbiome signatures, metabolic profiles and host markers compared to healthy individuals. Even though the field of microbiota analysis has emerged in the last few years and many reports associate microbial changes to various ailments, integrative studies that target the host-microbe interactions in diabetes are still in their infancy. To gain a better understanding of the biological processes linked to T2D, we will perform a detailed longitudinal multi-omic analysis of diabetic patients compared to healthy individuals targeting the microbiome, metabolome and resistome profiles. Altogether, these analyses will provide a rich source of data to characterize the host-microbe interactions associated with T2D.
Contract no.: PD 224
Project code: PN-III-P1-1.1-PD-2019-0499
Acronim: DOMINO
Project director:
Dr. Grațiela Grădișteanu
Objective: This study aims to correlate and integrate for the first time microbiome, resistome, metabolome and NOX profiles in type 2 diabetes patients. This innovative approach will broaden our understanding regarding the molecular features of a disease with epidemic proportions.
Expected results: The DOMINO study has the potential to significantly influence the scientific field. We will implement for the first time in Romania innovative experimental methods including intestinal microbiota next generation sequencing and metabolome analysis. During its implementation , the project will lead to a series of results including experimental data on microbiome, metabolome and NOX profiles of diabetic patients, integrative analysis algorithms, and publication of at least 2 high impact ISI papers.

RESEARCH
UB students invited to join the “Media Literacy in the Age of AI” ideathon
Events, Research, International, UB Student, Calls, Announcements, UB NewsPostări asemănătoare: MA Students, PhD Students and UB Researchers Invited to Join the Second Games of Science Edition and Bring Science Closer to the Public Students from all CIVIS member universities, invited by the Sapienza...
IDEAS coLABORATORY 4.0: UB students bring science closer to ctizens
Events, Research, UB Student, Science Communication, UB NewsPostări asemănătoare: Sign up for the IDEAS coLABORATORY 4.0 and let’s bring science closer to citizens! MA Students, PhD Students and UB Researchers Invited to Join the Second Games of Science Edition and Bring Science Closer to the...
On Wednesday, 5 November 2025, ICUB invites you to two hybrid events regarding various solutions for the development of a sustainable agriculture
Events, Research, International, Announcements, UB NewsPostări asemănătoare: 1.838 sustainable development experts trained by the University of Bucharest under the postgraduate program “Expert in Sustainable Development” Series of events under the title Geophysical and Geological Data for...
NEWS
The University of Bucharest welcomes NATO Secretary General Mark Rutte and hosts debate on “Strengthening Eastern Flank: NATO’s Vision for Romania”
Events, International, UB NewsPostări asemănătoare: University of Bucharest hosts student debate “Strengthening Eastern Flank: NATO’s vision for Romania”, with the participation of NATO Secretary General Mark Rutte The University of Bucharest Hosts the “Thirty...
UB students invited to join the “Media Literacy in the Age of AI” ideathon
Events, Research, International, UB Student, Calls, Announcements, UB NewsPostări asemănătoare: MA Students, PhD Students and UB Researchers Invited to Join the Second Games of Science Edition and Bring Science Closer to the Public Students from all CIVIS member universities, invited by the Sapienza...
University of Bucharest hosts student debate “Strengthening Eastern Flank: NATO’s vision for Romania”, with the participation of NATO Secretary General Mark Rutte
Press Releases, Events, UB NewsPostări asemănătoare: The University of Bucharest, important presence at the plenary meeting of the NATO Civil Protection Group, organized at the NATO headquarters in Brussels The University of Bucharest Hosts the “Thirty Years After –...
IDEAS coLABORATORY 4.0: UB students bring science closer to ctizens
Events, Research, UB Student, Science Communication, UB NewsPostări asemănătoare: Sign up for the IDEAS coLABORATORY 4.0 and let’s bring science closer to citizens! MA Students, PhD Students and UB Researchers Invited to Join the Second Games of Science Edition and Bring Science Closer to the...
The Magic of light returns to the Botanical Garden of the University of Bucharest – “Garden of Lights: Small World”
Events, UB NewsPostări asemănătoare: The Botanical Garden of the University of Bucharest once again turns into the Garden of Lights and brings to life the magical world of the Beauty and the Beast fairytale The Botanical Garden of the University of...
On Wednesday, 5 November 2025, ICUB invites you to two hybrid events regarding various solutions for the development of a sustainable agriculture
Events, Research, International, Announcements, UB NewsPostări asemănătoare: 1.838 sustainable development experts trained by the University of Bucharest under the postgraduate program “Expert in Sustainable Development” Series of events under the title Geophysical and Geological Data for...






