Antibiotic and silver resistance in bacterial strains isolated from leg ulcers
Abstract: Although there are numerous studies concerning biofilms of chronic wounds, by classic diagnostic methods or by association of molecular methods, there are not comparative data regarding resistance to antibiotics and antiseptics of the isolated microbial strains, responsible for the development of biofilms. Moreover, in Romania there is insufficient data regarding the specific composition and the involvement of the microbial biofilms in the process of the delayed healing of leg ulcers. The main objectives of the present project are: (1) Phenotypic and genotypic characterization of antibiotic resistance features in a collection of microbial strains isolated from leg ulcers; (2) Characterization of silver efficiency on microbial strains isolated from infections of leg ulcers in planktonic and adherent state; (3) Screening of synergic actions of silver and antibiotics against the chronic wounds isolates; (4) Demonstrating the efficacy and the advantages of the proposed combinatorial strategy comparing with classical methods for treatment of leg ulcers. The results of this project will have a positive impact on the public health through the improvement of quality of life of patients with leg ulcers by offering biological criteria and a selection methodology of optimal strategy for treating severe infections with multidrug resistant bacteria to antibiotics with the production of biofilms.
Contract no.: PD 200 din 27/08/2020
Acronim: SILVER-RES
Project director:
Georgescu Mihaela
georgescucmihaela@
Contract start date: 01.09.2020
Date of conclusion of the contract: 30.08.2022
Duration: 24 months (2020-2022)
Team members:
Prof. univ. dr. Veronica Lazăr
Dr. Georgescu Mihaela
Objective:
- Phenotypic and genotypic characterization of antibiotic resistance features in a collection of microbial strains isolated from leg ulcers;
- Characterization of silver efficiency on microbial strains isolated from infections of leg ulcers in planktonic and adherent state;
- Screening of synergic actions of silver and antibiotics against the chronic wounds isolates;
- Demonstrating the efficacy and the advantages of the proposed combinatorial strategy comparing with classical methods for treatment of leg ulcers.
Estimated results:
– collection of leg ulcers strains (at least 100), – Selection of the optimal association variants based on antibiotics, silver based antiseptics or association of the two of them regarding the microbicidial effect, anti-biofilm and reduced citotoxicity
– 2 ISI papers,
– 2 oral/ poster presentations;
– 3 annual scientific reports.
Total value from budget: 246.950,00 RON
Total value of the Contract: 246.950,00 RON
Article: Georgescu, Mihaela, Corneliu Ovidiu Vrancianu, Marcela Popa, Irina Gheorghe, and Mariana Carmen Chifiriuc. 2022. “First Report on the Phenotypic and Genotypic Susceptibility Profiles to Silver Nitrate in Bacterial Strains Isolated from Infected Leg Ulcers in Romanian Patients” Applied Sciences 12, no. 10: 4801. https://doi.org/10.3390/

RESEARCH
International Co-authored Article by FJSC Researcher Receives Award from the U.S. National Communication Association (NCA)
Press Releases, Research, International, Awards and Distinctions, UB NewsPostări asemănătoare: Oana Șerban Authored a Routledge Volume. “Cultural Capital and Creative Communication. (Anti-)Modern and (Non-)Eurocentric Perspectives” has just been published About the adaptation of Shakespeare’s plays to...
International Award for a Doctoral Thesis from the University of Bucharest in Natural Language Processing
Research, International, UB Student, Awards and Distinctions, Announcements, UB NewsPostări asemănătoare: The University of Bucharest, on the Podium of the International Competition Imperial Barell Award (IBA) UB doctoral and post-doctoral students, invited to register for the CIVIS Training for innovation and...
Science Meets High School Students at the University of Bucharest at the 2026 European Researchers’ Night
Events, Research, Announcements, UB NewsPostări asemănătoare: Tens of researchers of the University of Bucharest and thousands of participants involved in promoting modern science during Researchers’ Night ReCoNnect 2024 European Researchers’ Night 2024: science...
NEWS
International Co-authored Article by FJSC Researcher Receives Award from the U.S. National Communication Association (NCA)
Press Releases, Research, International, Awards and Distinctions, UB NewsPostări asemănătoare: Oana Șerban Authored a Routledge Volume. “Cultural Capital and Creative Communication. (Anti-)Modern and (Non-)Eurocentric Perspectives” has just been published About the adaptation of Shakespeare’s plays to...
International Award for a Doctoral Thesis from the University of Bucharest in Natural Language Processing
Research, International, UB Student, Awards and Distinctions, Announcements, UB NewsPostări asemănătoare: The University of Bucharest, on the Podium of the International Competition Imperial Barell Award (IBA) UB doctoral and post-doctoral students, invited to register for the CIVIS Training for innovation and...
University of Bucharest Kicks Off the 2026–2027 Academic Year. The Dates of the Opening Ceremonies
Events, UB Student, Announcements, UB NewsPostări asemănătoare: The opening of the new academic year of 2024-2025 at the University of Bucharest, an occasion to reaffirm the collaboration with the Bucharest City Hall The opening of the new academic year of 2024-2025 at the...
The UB Community Is Invited to Discover the Romanian Post from the Inside on World Post Day
Events, UB Student, Announcements, UB NewsPostări asemănătoare: The Balance of Durable Development: the UB community is invited to discover UN Durable Development Objectives at the Rectorate Discover Art Safari 2026: special tickets for the University of Bucharest community at...
Do You Have an Idea About How We Can Combat Disinformation? It Could Be Your Ticket to coLABORATORUL de IDEI 5.0
Events, UB Student, Announcements, UB NewsPostări asemănătoare: The University of Bucharest is partner in an international project to combat gender stereotypes, through TV series watched by teenagers...
70 Years of the CMR Convention: two international conferences and romania’s first moot court competition in transport law at the University of Bucharest, Faculty of Law
Events, International, UB Student, UB NewsPostări asemănătoare: Outstanding Results of the Team of Faculty of Law of the University of Bucharest at the “René Cassin” European Law Competition Professor Simina Tănăsescu, PhD, faculty member at the University of Bucharest’s Law...







