Teza de abilitare: Dezvoltarea de strategii pentru evaluarea in vitro a unor noi biomateriale 

Abilitare rezumat_Cimpean

Carti, monografii, cursuri

1. Cimpean, A., Ion, R., Ciofrangeanu, C., Mitran, V., Galateanu, B., Iordachescu, D., Ghid practic de evaluare in vitro a biocompatibilitătii implanturilor dentare, 2008, Editura Ars Docendi, 118 p., ISBN: 978-973-558-364-4.
2. Cimpean, A., Culturi de celule animale, 2006, Editura Ars Docendi, 214 p., ISBN-10 973-558-274-0; ISBN-13 978-973-558-274-6.
3. Iordachescu, D., Cimpean, A., Stan, C., 2004, Modelarea matricei extracelulare. Aplicatii in ingineria tisulara, Editura Pro-Transilvania, 245 p., ISBN 973-715-024-4.
4. Gavrila, M., Cimpean, A., Metoda de izolare și cultivare a celulelor stem mezenchimale umane, 2007, 71 p., Editura Curtea Veche, ISBN 978-973-9467-92-6.

Capitole carti

1. Cimpean, A., Ion, R., Gordin D.-M., Neacsu, P., Mitran, V., Gloriant, T., Biomaterials as modulators of macrophage inflammatory response, Biomaterials (vol. 11) in: J.N. Govil (Ed.), Nanotechnology series, Studium Press LLC (USA), 139-176 (2013).
2. Dimonie D, Petrache M, Doncea S, Gabor R, Vasile E, Cimpean A, Fierascu RC, Cristian N, Dinescu S, Trandafir I, Anton L, Fierascu I, Galateanu B. 2013. New approaches to develop 3D layer shaped scaffolds for soft tissue engineering, In: Advanced biocompatible structures for prospective bioengineering: Concepts and strategies, Editura Academiei Române, p. 74-124, ISBN: 978-973-27-2317-3.

Articole publicate în reviste indexate ISI (selectiv)

• Neacsu P, Staras AI, Voicu SI, Ionascu I, Soare T, Uzun S, Cojocaru VD, Pandele AM, Croitoru SM, Miculescu F, Cotrut CM, Dan I, Cimpean A. Characterization and In vitro and In vivo Assessment of a Novel Cellulose Acetate-coated Mg-based Alloy for Orthopaedic Applications, Materials, 2017, 10 (7), 686 (2017) http://www.mdpi.com/1996-1944/10/7/686/htm
• Voicu SI, Condruz RM, Mitran V, Cimpean A, Miculescu F, Andronescu C, Miculescu M, Thakur VK. Sericin Covalent Immobilization onto Cellulose Acetate Membrane for Potential Osseointegration Applications. ACS Sustainable Chem Eng, 4, 1765-1774 (2016). http://pubs.acs.org/doi/abs/10.1021/acssuschemeng.5b01756
• Ion R, Luculescu C, Cimpean A, Marx P, Gordin D-M, Gloriant T. Nitride coating enhances endothelialization on biomedical NiTi shape memory alloy. Mater Sci Eng C, 62, 686–691 (2016). http://www.sciencedirect.com/science/article/pii/S0928493116301217
• Castany P, Gordin D-M, Drob SI, Vasilescu C, Mitran V, Cimpean A, Gloriant T. Deformation mechanisms and biocompatibility of the superelastic Ti–23Nb–0.7Ta–2Zr–0.5N alloy. Shap Mem Superelasticity, 2, 18-28 (2016). http://link.springer.com/article/10.1007/s40830-016-0057-0
• Rusen L, Neacsu P, Cimpean A, Ion V, Brajnicova S, Dumitrescu LN, Banita J, Dinca V, Dinescu M. In vitro evaluation of poly(ethyleneglycol)-block-poly(e-caprolactone) methyl ether copolymer coating effects on cells adhesion and proliferation. Appl Surf Sci, 374, 23-30 (2016). http://www.sciencedirect.com/science/article/pii/S0169433215020383
• Ion R, Stoian AB, Dumitriu C, Grigorescu S, Mazare A, Cimpean A, Demetrescu I, Schmuki P. Nanochannels formed on TiZr alloy improve biological response. Acta Biomater, 24, 270-377 (2015). http://www.ncbi.nlm.nih.gov/pubmed/26092351
• Neacsu P, Mazare A, Schmuki P, Cimpean A. Attenuation of the macrophage inflammatory activity by TiO2 nanotubes via inhibition of MAPK and NF-kB pathways. Int J Nanomedicine, 10, 6455-6476 (2015).        http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608594/
• Mitran V, Vasilescu C, Drob SI, Osiceanu P, Calderon Moreno JM, Tabirca MC, Gordin DM, Gloriant T, Cimpean A. Biological behaviour and enhanced anticorrosive performance of the nitrided superelastic Ti-23Nb-0.7Ta-2Zr-0.5N alloy. BioMed Res Int, 125, article ID  261802 (2015). http://sci-hub.cc/10.1155/2015/261802
• Drob SI, Vasilescu C, Calderon Moreno JM, Osiceanu P, Neacsu P, Cimpean A, Gordin DM, Gloriant T. Multifunctional „gum metal” titanium-based alloy: Its long-term electrochemical behaviour and macrophage response. Int J Electrochem Sci, 10, 10738-10755 (2015). http://www.electrochemsci.org/papers/vol10/101210738.pdf
• Mitran V, Albu MG, Vasile E, Cimpean A, Costache M. Dose-related effects of sericin on preadipocyte behavior within collagen/sericin hybrid scaffolds. Prog Nat Sci Mater Internat, 25, 122-130 (2015). http://authors.elsevier.com/a/1R5SJ3Zr7s9kfE(free access)
• Neacsu P, Ion RN, Mitran V, Staras AI, Cimpean A. State of the art and recent patents on Mg-based biodegradable bone implants. Rec. Pat. Regen. Med., Vol. 4, Nr. 3, 168-188 (2015). DOI: 2174/2210296505666150205155811
• Ion R, Vizireanu S, Stancu CE, Luculescu C, Cimpean A, Dinescu Gh. Surface plasma functionalization influences macrophage behavior on carbon nanowalls, Mater Sci Eng C Mater Biol Appl, 48, 118-125 (2015). http://www.ncbi.nlm.nih.gov/pubmed/25579904
• Neacsu P, Gordin DM, Mitran V, Gloriant T, Costache M, Cimpean A. In vitro performance assessment of new beta Ti-Mo-Nb alloy compositions, Mater Sci Eng C Mater Biol Applic, 47, 105-113 (2015). http://www.ncbi.nlm.nih.gov/pubmed/25492178
• Neacsu P, Mazare A, Cimpean A, Park J, Costache M, Schmuki P, Demetrescu I.Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface, Int J Biochem Cell Biol, 55, 187-195 (2014).http://www.ncbi.nlm.nih.gov/pubmed/25220343
• Cimpean A, Vasilescu E, Drob P, Cinca I, Vasilescu C, Anastasescu M, Mitran V, Drob SI. Enhancement of the electrochemical behaviour and biological performance of Ti–25Ta–5Zr alloy by thermo-mechanical processing, Mater Sci Eng C Mater Biol Applic, 38, 127-142 (2014). http://www.ncbi.nlm.nih.gov/pubmed/24656361
• Cimpean A, Recent advances and challenges in adipose tissue engineering: Adipose derived stem cell-based approaches, Curr Tiss Eng, 3, 7-24 (2014). http://benthamscience.com/journal/abstracts.php?journalID=cte&articleID=119438
• Ion R, Gordin DM, Mitran V, Osiceanu P, Dinescu S, Gloriant T, Cimpean A, In vitro biocompatibility performances of the novel superelastic beta-type Ti-23Nb-0.7Ta-2Zr-0.5N alloy, Mater Sci Eng C Mater Biol Applic, 35, 411-419 (2014). http://www.ncbi.nlm.nih.gov/pubmed/24411395
• Ion R, Vasilescu C, Drob P, Vasilescu E, Cimpean A, Drob I, Gordin DM, Gloriant T. Long-term corrosion performances and cytocompatibility of nitrided Ti and Ti–6Al–4V alloy in severe functional conditions, Mater Corros, 65, 593-604 (2014). http://onlinelibrary.wiley.com/doi/10.1002/maco.201206724/abstract
• Mindroiu M, Ion R, Pirvu C, Cimpean A, Surfactant-dependent macrophage response to polypyrrole-based coatings electrodeposited on Ti6Al7Nb alloy, Mater Sci Eng C Mater Biol Applic, 33, 3353-3361 (2013).
  http://www.sciencedirect.com/science/article/pii/S0928493113002300
• Andronescu E, Ficai A, Albu M, Mitran V, Sonmez M, Ficai D, Ion R, Cimpean A. Collagen-hydroxyapatite/Cisplatin Drug Delivery Systems for Locoregional Treatment of Bone Cancer, Technol Cancer Res Treat, 12, 275-284 (2013). http://www.ncbi.nlm.nih.gov/pubmed/23547973
• Gordin DM, Gloriant T, Chane-Pane V, Busardo D, Mitran V, Hoche D, Vasilescu C, Drob SI, Cimpean A. Surface characterization and biocompatibility of titanium alloys implanted with nitrogen by Hardion+ technology, J Mater Sci: Mater Med, 23, 2953-2966 (2012).
  http://www.ncbi.nlm.nih.gov/pubmed/22918550
• Cimpean A, Mitran V, Ciofrangeanu CM, Galateanu B, Bertrand E, Gordin D-M, Iordachescu D, Gloriant T. Osteoblast cell behavior on the new beta-type Ti–25Ta–25Nb alloy, Mater Sci Eng C Mater Biol Applic, 32, 1554–1563 (2012).
  http://www.sciencedirect.com/science/article/pii/S0928493112001610
• Galateanu B., Dimonie D., Vasile E., Nae S., Cimpean A., Costache M., Layer-shaped Alginate Hydrogels Enhance the Biological Performance of Human Adipose-Derived Stem Cells, BMC Biotechnol 12, 35, http://www.biomedcentral.com/1472-6750/12/35 (2012). http://www.biomedcentral.com/1472-6750/12/35
• Galateanu B., Dinescu S., Cimpean A, Dinischiotu A, Costache M., Modulation of adipogenic conditions for prospective use of hADSCs in adipose tissue engineering, Int J Mol Sci, 13, 15881-15900, doi:3390/ijms130x000x(2012).
  http://www.ncbi.nlm.nih.gov/pubmed/23443100
• Dinescu S., Galateanu B., Albu M., Cimpean A., Dinischiotu A., Costache M., Sericin Enhances the Bioperformance of Collagen-Based Matrices Preseeded with Human-Adipose Derived Stem Cells (hADSCs), Int J Mol Sci, 14, 1870-1889; doi:3390/ijms14011870(2013).
  http://www.mdpi.com/1422-0067/14/1/1870
• Vasilescu C, Calderon Moreno JM, Cimpean A, Cojocaru D, Cinca I, Andronescu E, Grigore F, Galateanu B, Drob SI, Synthesis, mechanical and structural properties and biological activity of some nanostructured bone scaffolds, Digest J Nanomat Biostr, 6, 523-534 (2011). http://connection.ebscohost.com/c/articles/74592904/synthesis-mechanical-structural-properties-biological-activity-some-nanostructured-bone-scaffolds
• Cimpean A, Popescu S, Ciofrangeanu CM, Gleizes AN. Effects of LP-MOCVD prepared TiO2 thin films on the in vitro behavior of gingival fibroblasts, Mat Chem Phys, 125, 485-492 (2011).
  http://www.sciencedirect.com/science/article/pii/S025405841000859X
• Raducanu D, Cimpean A, Vasilescu E, Cojocaru VD, Cinca I, Drob P, Ivanescu S. Corrosion behaviour and biocompatibility of a new dental noble AuPdAgTi alloy, Mater Corros, 61, 775-782 (2010). http://onlinelibrary.wiley.com/doi/1002/maco.201005636/abstract
• Scorei RI, Ciofrangeanu C, Ion R, Cimpean A, Galateanu B, Mitran V, Iordachescu D. In Vitro Effects of Calcium Fructoborate upon Production of Inflammatory Mediators by LPS-stimulated RAW 264.7 Macrophages, Biol Trace Elem Res,135, 334-344 (2010).
  http://www.ncbi.nlm.nih.gov/pubmed/19669712
• Scorei R, Ciubar R, Ciofrangeanu CM, Mitran V, Cimpean A, Iordachescu D. Comparative effects of boric acid and calcium fructoborate on breast cancer cells, Biol Trace Elem Res, 122, 197-205 (2008).
  http://www.ncbi.nlm.nih.gov/pubmed/18176783
• Popa MV, Demetrescu I, Iordachescu D, Cimpean A, Vasilescu E, Drob P, Vasilescu C, Istratescu M, The relation between electrochemical tests and in vitro evaluation of titanium alloy biocompatibility, Mater Corros, 58, 667-675 (2007).
  http://onlinelibrary.wiley.com/doi/1002/maco.200704053/abstract
• Ciubar R, Ciofrangeanu C, Mitran V, Cimpean A, Stanescu A, Iordachescu D, The effect of lead ions on human erythrocytes in vitro, Rev Chim – Bucharest, 9, 895-808 (2007).
  http://revistadechimie.ro/pdf/CIUBAR%20R..pdf
• Scorei R, Ciubar R, Iancu C, Mitran V, Cimpean A, Iordachescu D, In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophils granulocytes, Biol Trace Elem Res, 118, 27-37 (2007).
  http://link.springer.com/article/10.1007%2Fs12011-007-0019-7#page-1
• Ciubar R, Mitran V, Cimpean A, Iordachescu D, In vitro effects of nickel on human embrionary lung fibroblasts, Rev Roum Chim, 51, 199-203, 2006.
  http://revroum.getion.ro/wp-content/uploads/2006/RRC_3_2006/Art.%2006.pdf
• Cimpean A, Stefan C, Gijsbers R, Stalmans W, Bollen M, Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2, Biochem J, 381, 71-77 (2004).
  http://www.ncbi.nlm.nih.gov/pubmed/15096095

Cursuri

Licenţă

– Biochimie clinica

Cursul (20 h) se adreseaza studentilor din anul III de studiu din cadrul ciclului de Licenta – sectia Biochimie si abordeaza urmatoarele subiecte:

1. Introducere in patologia clinica si aplicatiile biochimiei medicale in diagnosticul de laborator;
2. Sangele:Plasma si celule specializate; Anemii: pernicioasa, hemolitice; Boli asociate perturbarii metabolismului fierului; Hemoglobinopatii;
3. Disfunctii hepatice si biliare: Teste biochimice ale functiei ficatului; Boli hepato-biliare: icterele, hiperbilirubinemii prin defecte genetice in metabolismul bilirubinei, fibroza/ciroza hepatica;
4. Afectiuni ale pancreasului: pancreatite acuta si cronica, fibroza chistica a pancreasului (mucoviscidoza), insuficienta pancreatica, diabetul zaharat (diabetul de tip 1, diabetul de tip 2, diabetul gestational);
5. Patofiziologia renala: Componente patologice in urina; Boli renale: boli glomerulare (glomerulonefrite, sindrom nefrotic), boli tubulare (acidoza tubulara renala), infectiile tractului urinar, obstructiile tractului renal, insuficienta renala, nefropatia diabetica, hipertensiunea renala;
6. Patofiziologia inimii: Enzime din celulele miocardice importante din punct de vedere clinic; Conditii patologice ce afecteaza inima: boala ischemica a inimii/infarctul miocardic, insuficienta cardiaca, cardiomiopatia, aritmiile cardiace, bolile valvulare ale inimii;
7. Patofiziologia arteriala: ateroscleroza, hipertensiunea arteriala, hipotensiunea arteriala.

Master

– Aspecte teoretice si practice ale culturilor de celule animale

Cursul (28 h) se adreseaza studentilor din anul I de studiu din cadrul Masterului de Biochimie si Biologie Moleculara si abordeaza urmatoarele subiecte:

1. Istoric, obiective, avantajele si dezavantajele culturilor celulare;
2. Sisteme de cultivare a celulelor animale: Culturile tisulara, de organ si de celule; Culturile organotipica si histotipica; Culturi la densitati celulare mari si clonale; Culturi de celule aderente si in suspensie; Culturi primare, linii celulare finite si continue;
3. Medii de cultura si conditii de cultivare;
4. Ciclul de creştere si proliferarea celulelor in cultura;
5. Sincronizarea celulara: Metode chimice; Metode fizice;
6. Imortalizarea celulara;
7. Transfectia celulara: Tipuri de transfectie; Conditii specifice de cultivare a celulelor; Metode de transfectie celulara;
8. Transformarea celulara: Instabilitatea genomica; Imortalitatea celulara; Controlul aberant al cresterii celulare; Tumorigenicitatea celulelor transformate;
9. Senescenta celulara: Tipuri de senescenta si caracteristicile celulelor senescente; Cai moleculare de activare a senescentei celulare; Mecanisme de inducere a senescentei;
10. Latenta celulara, diferentierea si de-diferentierea celulara;
11. Citometria in flux;
12. Aplicatii ale culturilor celulare in obtinerea anticorpilor monoclonali.

Bibliografie selectiva:

• Practical Cell Analysis, D. Pappas, John Wiley & Sons, Ltd, 2010.
• Methods in biotechnology, Animal Cell Biotechnology, Methods and Protocols, 2nd Ed., R. Pörtner (Ed.), Humana Press Inc., 2007.
• Culturi de celule animale, A. Cimpean, Editura Ars Docendi, 2006 (ISBN-10 973-558-274-0; ISBN-13 978-973-558-274-6).
• Culture of animal cells. A manual of basic technique, R.I. Freshney, 5th Edition, Wiley Liss, Inc., p. 89-120, 2006.
• Animal Cell Culture and Technology, M. Butler, Garland Science/BIOS Scientific Publishers, G. Bushell (Ed), 2004.
• Senescence and immortalization: role of telomeres and telomerase, J.W. Shay, W.E. Wright, Carcinogenesis, 26, 867-874, 2005.
• The signals and pathways activating cellular senescence, I. Ben-Porath, R.A. Weinberg, Int. J. Biochem. Cell Biol., 37, 961-976, 2005.
• Synchrony in human, mouse and bacterial cell cultures, C.E. Helmstetter, M. Thornton, A. Romero, K. Leigh Eward, Cell Cycle, 2, 42-45, 2003.
• Animal Cell Culture, A Practical Approach, 3rd Edition, J.R.W. Masters, Oxford University Press, 2000.
• Cell separation methods and applications, D. Recktenwald, A. Radbruch (Eds), Marcel Dekker, Inc., 1998.
• Laboratory techniques in biochemistry and molecular biology, R.H. Burdon, P.H. van Knippenberg, Cell culture for biochemists, 2nd revised edition, R.L.P. Adams, Elsevier Amsterdam. New York. Oxford, Elsevier Science Publishers B. V. (Biomedical Division), 1990.

– Introducere in ingineria tisulara

Cursul (14 h) se adreseaza studentilor din anul II de studiu din cadrul Masterului de Biochimie si Biologie Moleculara si abordeaza urmatoarele subiecte:

1. Introducere in ingineria tisulara;
2. Principii de baza ale ingineriei tisulare in vitro si in vivo: componenta celulara (celule stem, celule diferentiate), structura „scaffold” (matrici polimerice), semnale celulare;
3. Biocompatibilitate: teste in vitro de evaluare a biocompatibilitatii (teste incluse in standardele ISO 10993-5; teste de evaluare a interactiilor celule-biomaterial); teste in vivo de evaluare a biocompatibilitatii (testul de sensibilitate, reactivitate intracutanata, toxicitate sistemica, genotoxicitate, carcinogenicitate etc.);
4. Aplicatii ale ingineriei tisulare in medicina regenerativa: Ingineria tisulara a pielii; Regenerarea tesutului osos si ingineria tisulara; Reconstructia cartilajului articular prin inginerie tisulara; Ingineria tisulara vasculara; Ingineria tisulara a ficatului.

Bibliografie selectiva:

• Biological Interactions on Materials Surfaces, D.A. Puleo, R. Bizios (Eds), Springer Science+Business Media, LLC 2009.
• Biomedical Materials, Springer Science+Business Media, LLC, R. Narayan, 2009.
• Cimpean, R. Ion, C. Ciofrangeanu, V. Mitran, B. Galateanu, D. Iordachescu, Ghid practic de evaluare in vitro a biocompatibilitatii implanturilor dentare, Editura Ars Docendi, 2008, ISBN: 978-973-558-364-4.
• Cell culture models of higher complexity in tissue engineering and regenerative medicine, C.J. Kirkpatrick, S. Fuchs, M.I. Hermanns, K. Peters, R.E. Ungerr, Biomaterials, 28, 5193-5198, 2007.
• Culture of cells for tissue engineering, G. Vunjak-Novakovic, R.I. Freshney, John Wiley & Sons, Inc. All, 2006.
• Bone graft and bone substitutes, Basic Science and Clinical Applications, A. Nather, World Scientific Publishing Co. Pte. Ltd., 2005.
• Modelarea matricei extracelulare. Aplicatii in ingineria tisulara, D. Iordachescu, A. Cimpean, C. Stan, Edit. Pro-Transilvania, 2004, ISBN 973-715-024-4.
• Principles of Clinical Cell-Based Tissue Engineering, G.F. Muschler, C. Nakamoto, L.G. Griffith, J. Bone Joint Surg., 86, 1541-1558, 2004.
• Principles of tissue engineering, 2nd Edition, R.P. Lanza, R. Langer, J. Vacanti, Academic Press, 2004.
• An introduction to tissue-biomaterial interactions, R. Bizios, K.C. Dee, D.A. Puleo, John Wiley & Sons, Inc., 2002.

Articole publicate în reviste cu referenți (selectiv) (1998-2007)

1. Cimpean A, Caloianu M, Zarnescu O, Moldovan L, Efimov N, Ranga O, Structural, ultrastructural and biochemical aspects of the cartilaginous extracellular matrix degradation in human knee osteoarthritic lesions, J Med Biochem, 2, 4, 313-322 (1998).Articol
2. Cimpean A, Caloianu M, Zarnescu O, Bojinca M, Synovial Membrane Pathology and its Implication in Human Osteoarthritis, J Med Biochem, 3, 4, 379-387 (1999).Articol
3. Cimpean A, Caloianu M, Zarnescu O, Bojinca M, Synovial fluid alterations in human rheumatoid arthritis, J Med Biochem, 3, 1, 79-86 (1999).Articol
4. Cimpean A, Caloianu M, Alexandru D, Efimov N, Buzgariu W, Effect of the interleukin-1b on gelatinolytic activity and cell morphology of human osteoarthritic chondrocytes in culture, J Med Biochem, 4, 2, 113-129 (2000).Articol
5. Cimpean A, Zarnescu O, Caloianu M, Moldovan L, Efimov N, Glycosaminoglycan synthesis by human osteoarthritic chondrocytes cultured in alginate beads, Roum Biotechnol Lett, 5, 2, 127-135 (2000).Articol
6. Cimpean A, Moldovan L, Flamanzeanu M, Nicolae C, In vitro polymolecular aggregation and ultrastructural characterization of the osteoarthritic cartilage proteoglycans, Rev Roum Biol – Biol Anim, Tome 46, 1-2, 85-92 (2001).Articol
7. Moldovan L, Zarnescu O, Oancea A, Cimpean A, Constantinescu L, Corneal collagen interaction with proteoglycans and glycosaminoglycans, Roum Biotechnol Lett, 5, 2, 137-145 (2002).Articol
8. Buzgariu W, Zarnescu O, Caloianu M, Cimpean A, Titescu G, Stefanescu I, Effects of heavy water on ultrastructural and functional status of HEP2 and CHO cells lysosomes, Revue Roum Biol- Biol Anim, Tome 47, 1-2, 87-96 (2002).Articol
9. Cimpean A, Caloianu M, Zarnescu O, Batrana D, Cartilage alterations in human osteoarthritis, Rom J Biol Sci, IV, 1-4, 27-34 (2002).Articol
10. Cimpean A, Zarnescu O, Moldovan L, Nicolae C, Flamanzeanu M, In vitro evaluation of biosynthetic activity of the human osteoarthritic chondrocytes embedded in collagen gel, Roum Biotechnol Lett, 7, 6, 987-994 (2002).Articol
11. Moldovan L, Cimpean A, Flamanzeanu M, Nicolae C, Dumitrescu D, Matrix metalloproteinases involved in injured corneal tissue remodelling, Roum Biotechnol Lett, 7, 1, 14-27 (2002).Articol
12. Homeghiu CL, Bucata G, Bonoiu A, Stan C, Mitran V, Cimpean A, Iordachescu D, In vitro effects of transforming growth factor b1 in a cadmium chloride model of lung injury, Rom J Biophys, 14, 21-28 (2004).Articol
13. Stan C, Cimpean A, Iordachescu D, Cellular and molecular changes of psoriatic keratinocytes in response to UVA in vitrotreatment, Rom J Biophys, 14, 1-4, 1-12 (2004).Articol
14. Cimpean A, Endogenous proteases involved in human osteoarthritic cartilage degradation, Analele Universitatii Bucuresti, LIII, 15-26 (2004).Articol
15. Cimpean A, Zarnescu O, An ultrastructural study of cartilage alterations in human osteoarthritis, Revue Roum Biol- Biol Anim, Tome 50, 1-2, 99-105 (2005).Articol
16. Cimpean A, Zarnescu O, Stan C, Diaconeasa A, Nae S, Iordachescu D, Studii comparative privind exprimarea moleculelor Bcl-2 si Bax de catre keratinocitele normale si psoriazice, Analele Societatii Nationale de Biologie Celulara, IX, Nr. 2, 257-261 (2005).Articol
17. Neagos D, Mitran V, Chiracu G, Cimpean A, Cocos R, Iordachescu D, Effects of insulin, retinoic acid and hydrocortisone on in vitro dermal wound healing model, Rom J Biophys, 16, 93-102 (2006).Articol
18. Ciubar R, Mitran V, Bonoiu A, Cimpean A, Iordachescu D, The effect of nickel on the fibroblast mediated collagen matrix contraction, Rom J Biophys, 16, 125-133 (2006).Articol
19. Neagos D, Mitran V, Chiracu G, Ciubar R, Iancu C, Stan C, Cimpean A, Iordachescu D, Skin wound healing in a free floating fibroblast populated collagen latice model, Rom J Biophys, 16, 157-168 (2006).Articol
20. Stan C, Cimpean A, Zarnescu O, Iordachescu D, Pattern of keratin distribution in cultured psoriatic keratinocytes, Dermato.ro., 15, 36-39, 2007.Articol

Proiecte

Proiect PCE 188

PN-II-ID-JRP-2012

PCCA-195-2014

PED-149-2017

PCE-55-2017

Manunet-31-2017